Description

1-Methyl-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Pyrrolo[2,3-B]Pyridine is a high-value, advanced pharmaceutical intermediate belonging to the class of heterocyclic organoboron compounds. This compound is a critical building block in modern medicinal chemistry, enabling the efficient construction of complex molecular architectures through cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS therapeutic areas.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key boronic ester reagent for constructing carbon-carbon bonds in complex molecule synthesis.
• Pharmaceutical Intermediate: For the research and development of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: As a building block for creating new active ingredients with specific biological activity.
• Material Science Research: In the development of organic electronic materials, such as OLEDs and semiconductors, where the pyrrolopyridine core is valuable.
• Chemical Biology & Proteomics: Used in the synthesis of molecular probes and tools for studying biological systems.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical and biotech companies.

Basic Information

Product Name	1-Methyl-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Pyrrolo[2,3-B]Pyridine
CAS No.	912331-71-6
Molecular Formula	C16H23BN2O2
Molecular Weight	286.18 g/mol
Synonyms	1-Methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 2-(1-Methyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-Methyl-2-(pinacolatoboryl)-1H-pyrrolo[2,3-b]pyridine; 1-Methyl-1H-pyrrolo[2,3-b]pyridine-2-boronic acid pinacol ester; Pinacol 1-Methyl-1H-pyrrolo[2,3-b]pyridine-2-boronate; 912331-71-6 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our production of 1-Methyl-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Pyrrolo[2,3-B]Pyridine adheres to stringent quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to quality supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.