Description

8-Fluoroisochroman-4-Amine is a specialized fluorinated organic building block featuring a fused isochroman ring system. This compound is of significant value in pharmaceutical and agrochemical research as a key intermediate for the synthesis of novel active molecules. It is particularly sought after by R&D chemists and process development scientists working in medicinal chemistry and fine chemical synthesis. The unique structural motif of the fluorinated isochroman core enables the exploration of new chemical space in drug discovery programs.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of potential drug candidates, especially in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to modulate the bioavailability, potency, and metabolic stability of lead compounds.
• Agrochemical Development: Serves as a precursor in the creation of new herbicides, fungicides, or insecticides with enhanced properties.
• Ligand and Catalyst Synthesis: Can be utilized to construct novel chiral ligands or organocatalysts for asymmetric synthesis.
• Material Science Research: Potential monomer or precursor for developing advanced polymers with specific fluorinated characteristics.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.

Basic Information

Product Name	8-Fluoroisochroman-4-Amine
CAS No.	911826-00-1
Molecular Formula	C9H10FNO
Molecular Weight	167.18 g/mol
Synonyms	4-Amino-8-fluoroisochroman; 8-Fluoro-3,4-dihydro-1H-isochromen-4-amine; 8-Fluoro-1,2,3,4-tetrahydroisochromen-4-amine; 8-Fluoro-3,4-dihydroisochromen-4-amine; 8-Fluoro-4-aminoisochroman; 8-Fluoro-1,2,3,4-tetrahydro-4-aminoisoquinoline (tautomer); FICA (abbreviation); 911826-00-1
EINECS	Contact for details

Quality Control

Our 8-Fluoroisochroman-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with the standards required for research and development, as well as pre-clinical scale synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.