Description

5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridine-2-Carboxylic Acid Diethylamide is a high-value, organoboron building block essential for modern synthetic chemistry. This compound matters because it serves as a key intermediate in the synthesis of complex molecules, particularly through cross-coupling reactions like the Suzuki-Miyaura reaction. Pharmaceutical, agrochemical, and advanced materials research and development teams need this precise chemical to construct novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging the pyridine-boronic ester moiety for structural diversification.
• Material Science Research: Serves as a building block for creating organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester group makes it a stable and reactive partner for palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and labeled compounds for biological target identification and study.
• Custom Synthesis & Contract Manufacturing: An important starting material for fine chemical and custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridine-2-Carboxylic Acid Diethylamide
CAS No.	911227-46-8
Molecular Formula	C18H29BN2O3
Molecular Weight	332.25 g/mol
Synonyms	2-(Diethylcarbamoyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinic acid diethylamide; N,N-Diethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamide; 911227-46-8; Pyridine-2-carboxylic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, diethylamide
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridine-2-Carboxylic Acid Diethylamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.