Description

1-Methyl-4-(2-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenoxy]-Ethyl)-Piperazine is a sophisticated boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a protected boronic acid group with a piperazine moiety, enabling its use in complex coupling reactions and as a precursor for active pharmaceutical ingredients. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality reagents for Suzuki-Miyaura cross-coupling and other palladium-catalyzed transformations.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in constructing biaryl and heterobiaryl scaffolds common in kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds, a fundamental step in medicinal chemistry and material science.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require complex aromatic structures.
• Ligand and Catalyst Development: The piperazine group can be utilized to develop novel ligands for catalysis or functional materials.
• Polymer and Material Science: Acts as a monomer or functionalization agent in the creation of advanced polymers, OLED materials, and organic electronic components.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	1-Methyl-4-(2-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenoxy]-Ethyl)-Piperazine
CAS No.	910462-34-9
Molecular Formula	C19H31BN2O3
Molecular Weight	346.27 g/mol
Synonyms	4-[2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]-1-methylpiperazine; 1-Methyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazine; 2-[4-[2-(4-Methyl-1-piperazinyl)ethoxy]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-1,3,2-dioxaborolane; 910462-34-9; Boronic ester piperazine derivative; Piperazine boronic ester pinacol ester.
EINECS	Contact for details

Quality Control

Our production of 1-Methyl-4-(2-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenoxy]-Ethyl)-Piperazine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We operate under a quality management system and can support development projects requiring compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.