Description

n-[2-Methyl-3-(4,4,5,5-Tetramethyl[1,3,2]Dioxaborolan-2-Yl)Phenyl]-4-(tert-Butyl)Benzamide is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern medicinal chemistry and drug discovery. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring aryl-aryl bond formation.
• Suzuki-Miyaura Cross-Coupling Reagent: The protected boronic ester moiety serves as a stable and reactive handle for palladium-catalyzed coupling with aryl halides, enabling the construction of biaryl systems.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate complex aromatic structures.
• Material Science: Potential precursor for the synthesis of organic electronic materials, such as those used in OLEDs or organic photovoltaics, where defined conjugated structures are essential.
• Chemical Biology & Proteomics: Can be employed as a molecular probe or linker in bioconjugation strategies and target identification studies.
• Academic & Contract Research: Serves as a specialized reagent for methodology development and synthetic route exploration in university and CRO laboratories.

Basic Information

Item	Detail
Product Name	n-[2-Methyl-3-(4,4,5,5-Tetramethyl[1,3,2]Dioxaborolan-2-Yl)Phenyl]-4-(tert-Butyl)Benzamide
CAS No.	910235-65-3
Molecular Formula	C24H32BNO3
Molecular Weight	393.33 g/mol
Synonyms	4-tert-Butyl-N-[2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]benzamide; 2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-[4-(tert-butyl)benzoyl]aniline; 910235-65-3; 4-(tert-Butyl)-N-[2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]benzamide; Boronic ester intermediate CAS 910235-65-3; Pinacol boronate ester derivative
EINECS	Contact for details

Quality Control

Every batch of n-[2-Methyl-3-(4,4,5,5-Tetramethyl[1,3,2]Dioxaborolan-2-Yl)Phenyl]-4-(tert-Butyl)Benzamide is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our products are supported by a detailed Certificate of Analysis (COA) that includes data from NMR (1H, 13C, 11B), HPLC, and mass spectrometry. We adhere to cGMP guidelines where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be sealed under an inert atmosphere (argon or nitrogen) after each use to maintain stability and prevent hydrolysis of the boronic ester. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (1H, 13C)
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.