Description

Dibutyl (2-(Trifluoromethyl)Cyclopropyl)Boronate is a specialized organoboron reagent featuring a unique cyclopropyl ring substituted with a trifluoromethyl group. This compound is valued for its role as a key synthetic intermediate in advanced organic transformations, particularly in cross-coupling reactions. It is essential for researchers and process chemists in the pharmaceutical and agrochemical industries seeking to incorporate the metabolically stable trifluoromethylcyclopropyl moiety into novel active molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) containing the trifluoromethylcyclopropyl group, which can enhance metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the specific steric and electronic properties of the moiety are beneficial.
• Material Science Research: Serves as a precursor for creating advanced organic materials, including liquid crystals and polymers with tailored properties.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a boronate ester coupling partner for the introduction of the (2-(trifluoromethyl)cyclopropyl) fragment into complex organic architectures.
• Medicinal Chemistry & Drug Discovery: Enables the rapid exploration of chemical space in lead optimization and scaffold-hopping campaigns within high-throughput screening libraries.
• Fluorine Chemistry: A valuable reagent for studying the effects of fluorine substitution in small, strained ring systems.

Basic Information

Product Name	Dibutyl (2-(Trifluoromethyl)Cyclopropyl)Boronate
CAS No.	909698-11-9
Molecular Formula	C12H22BF3O2
Molecular Weight	266.11 g/mol
Synonyms	Dibutyl (2-(Trifluoromethyl)cyclopropyl)boronate; (2-(Trifluoromethyl)cyclopropyl)boronic acid dibutyl ester; B-(2-(Trifluoromethyl)cyclopropyl)boronic acid dibutyl ester; Dibutyloxyboranyl(2-(trifluoromethyl)cyclopropane); 909698-11-9; (2-Trifluoromethylcyclopropyl)boronic acid dibutyl ester; Dibutyl (2-Trifluoromethylcyclopropyl)boronate
EINECS	Contact for details

Quality Control

Our Dibutyl (2-(Trifluoromethyl)Cyclopropyl)Boronate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.