Description

1-Bromo-2-Chloro-3-Fluoro-4-Methoxybenzene is a high-purity, multi-halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the halogen and methoxy groups contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic cores for electronic materials used in displays and organic light-emitting diodes (OLEDs).
• Functional Polymer Monomer: Employed to introduce halogenated aromatic units into polymer backbones, modifying thermal stability, solubility, and optical properties.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Buchwald-Hartwig) due to the orthogonal reactivity of the bromo and chloro substituents.
• Chemical Research & Development: A versatile building block in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	1-Bromo-2-Chloro-3-Fluoro-4-Methoxybenzene
CAS No.	909122-27-6
Molecular Formula	C7H5BrClFO
Molecular Weight	239.47 g/mol
Synonyms	2-Bromo-1-Chloro-6-Fluoro-3-Methoxybenzene; 4-Methoxy-2-Bromo-1-Chloro-3-Fluorobenzene; 1-Bromo-2-chloro-3-fluoro-4-methoxy-benzene; Benzene, 1-bromo-2-chloro-3-fluoro-4-methoxy-; 3-Fluoro-4-methoxy-2-bromo-1-chlorobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Chloro-3-Fluoro-4-Methoxybenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.