Description

(2R,3R)-2-(4-Nitrophenyl)-3-(Perfluorophenyl)Oxirane is a high-value, chiral epoxide building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a nitroaromatic and a perfluorinated aromatic group, makes it a critical intermediate for constructing complex molecules with specific stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where fluorinated motifs are desired to modulate bioavailability, stability, and binding affinity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and pesticides, where the perfluorophenyl group can enhance lipid permeability and environmental persistence.
• Ligand and Catalyst Development: Acts as a starting material for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Advanced Material Research: Employed in the development of specialty polymers and liquid crystals, where its fluorinated component can impart unique surface properties and chemical resistance.
• Fluorine Chemistry Studies: A valuable model compound for investigating the reactivity and electronic effects of perfluoroaromatic systems in ring-opening reactions.

Basic Information

Product Name	(2R,3R)-2-(4-Nitrophenyl)-3-(Perfluorophenyl)Oxirane
CAS No.	908838-31-3
Molecular Formula	C14H6F5NO3
Molecular Weight	331.20 g/mol
Synonyms	(2R,3R)-2-(4-Nitrophenyl)-3-(pentafluorophenyl)oxirane; (2R,3R)-2-(4-Nitrophenyl)-3-(2,3,4,5,6-pentafluorophenyl)oxirane; (2R,3R)-rel-2-(4-Nitrophenyl)-3-(perfluorophenyl)oxirane; Pentafluorophenyl Nitrostyrene Oxide (R,R)-isomer; (R,R)-2-(4-Nitrophenyl)-3-(perfluorophenyl)oxirane; 2-(4-Nitrophenyl)-3-(pentafluorophenyl)oxirane (R,R)-form
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity for this advanced intermediate. Our standard offering meets a typical purity specification of ≥97% (by HPLC), with enantiomeric excess (ee) ≥99% for the (2R,3R) isomer. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity (IR, NMR), purity (HPLC), chiral purity (Chiral HPLC), and residual solvent content. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and light-sensitive nature. Keep away from strong bases and oxidizing agents. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (2R,3R)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.