Description

Z-1-Bromo-2-(2-Iodo-Vinyl)-Benzene is a high-value, halogenated aromatic building block featuring both bromine and iodine substituents on a vinylbenzene scaffold. This unique bifunctional structure makes it a critical intermediate for advanced organic synthesis, particularly in cross-coupling reactions like Suzuki and Stille couplings. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those requiring complex halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the vinyl halide functionality enables further structural elaboration.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Heck, Stille) due to the differential reactivity of the bromo and iodo groups, allowing for sequential functionalization.
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of molecular probes, imaging agents, and compound libraries for high-throughput screening.
• Academic & Industrial R&D: A versatile reagent for methodological development in organic synthesis and catalysis research.

Basic Information

Item	Detail
Product Name	Z-1-Bromo-2-(2-Iodo-Vinyl)-Benzene
CAS No.	908333-96-0
Molecular Formula	C8H6BrI
Molecular Weight	308.94 g/mol
Synonyms	1-Bromo-2-[(Z)-2-iodoethenyl]benzene; (Z)-1-Bromo-2-(2-iodovinyl)benzene; (Z)-2-Bromo-1-(2-iodovinyl)benzene; Benzene, 1-bromo-2-[(Z)-2-iodoethenyl]-; 2-Bromo-(Z)-β-iodostyrene; (Z)-β-Iodo-2-bromostyrene; Z-1-Bromo-2-(2-iodovinyl)benzene; 908333-96-0
EINECS	Contact for details

Quality Control

Every batch of Z-1-Bromo-2-(2-Iodo-Vinyl)-Benzene is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), isomeric purity (Z-isomer content), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere to maximize shelf-life and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (Z-isomer, HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.