Description

Pyrrolidine, 2-[Bis[3,5-Bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]-, (2R)- is a sophisticated, chiral organofluorine building block and a key intermediate in advanced organic synthesis. Its value lies in the unique combination of a chiral pyrrolidine scaffold with electron-deficient perfluorinated aryl groups and a silyl-protected alcohol, enabling precise stereochemical control in complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel materials where fluorination and specific stereochemistry are critical for performance.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Asymmetric Catalyst Ligand Precursor: Serves as a precursor for developing proprietary chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Used in the discovery and development of next-generation herbicides and pesticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Material Science: Employed in the synthesis of specialty polymers and advanced organic electronic materials that require fluorinated aromatic systems.
• Process Chemistry & Scale-up: Provides a reliable, high-purity starting point for optimizing synthetic routes from laboratory to pilot plant and commercial production scales.
• Academic & R&D: A valuable tool for methodological studies in organic chemistry, particularly in reactions involving fluorinated arenes and stereoselective C–H functionalization.

Basic Information

Item	Details
Product Name	Pyrrolidine, 2-[Bis[3,5-Bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]-, (2R)-
CAS No.	908303-26-4
Molecular Formula	C30H28F12NOSi
Molecular Weight	698.62 g/mol
Synonyms	(2R)-2-({Bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl})pyrrolidine; (R)-2-((Bis(3,5-bis(trifluoromethyl)phenyl)((trimethylsilyl)oxy)methyl)pyrrolidine; TMS-Protected Chiral Pyrrolidine Fluorinated Alcohol; Chiral Fluorinated Pyrrolidine Silyl Ether; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of our (2R)-Pyrrolidine derivative is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and enantiomeric excess. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from chiral HPLC, 1H/19F/13C NMR, and mass spectrometry. Our commitment to consistent high purity and reliable supply supports critical R&D and cGMP-compliant production processes for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.