Description

1H-Indole-1-Carboxylic Acid, 2-Borono-6-(Trifluoromethoxy)-, 1-(1,1-Dimethylethyl) Ester is a high-value, multi-functional boron-containing indole derivative. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in modern organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions. It is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronic ester functionality makes it an ideal partner for palladium-catalyzed coupling reactions to form biaryl and heterobiaryl structures, a cornerstone of medicinal chemistry.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging the indole and trifluoromethoxy motifs for enhanced biological activity and metabolic stability.
• Material Science Precursor: Employed in the synthesis of organic electronic materials, such as OLEDs and semiconductors, where its conjugated structure is beneficial.
• Chemical Biology Probe Development: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial scale-up projects.

Basic Information

Item	Details
Product Name	1H-Indole-1-Carboxylic Acid, 2-Borono-6-(Trifluoromethoxy)-, 1-(1,1-Dimethylethyl) Ester
CAS No.	906644-32-4
Molecular Formula	C15H17BF3NO4
Molecular Weight	343.11 g/mol
Synonyms	2-Borono-6-(trifluoromethoxy)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 2-borono-6-(trifluoromethoxy)-1H-indole-1-carboxylate; 6-(Trifluoromethoxy)-1H-indole-2-boronic acid tert-butyl ester; 2-Boron-6-(trifluoromethoxy)-1H-indole-1-carboxylic acid tert-butyl ester; Boronic acid, B-[6-(trifluoromethoxy)-1H-indol-2-yl]-, 1,1-dimethylethyl ester; tert-Butyl 6-(trifluoromethoxy)-1H-indole-2-boronate
EINECS	Contact for details

Quality Control

Every batch of our 1H-Indole-1-Carboxylic Acid, 2-Borono-6-(Trifluoromethoxy)-, 1-(1,1-Dimethylethyl) Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for pharmaceutical R&D and process chemistry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and LC-MS is supplied with each shipment. Specifications can be aligned with ICH guidelines for stability and impurity reporting.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.