Description

2-Morpholin-4-Yl-5-(Trifluoromethyl)Benzeneboronic Acid, Pinacol Ester is a high-value, organoboron building block designed for advanced synthetic chemistry. This compound is critical for enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is foundational for constructing complex molecular architectures. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl and morpholine motifs for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the boronic ester functionality for efficient carbon-carbon bond formation.
• Material Science Research: Serves as a precursor in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular structure is paramount.
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl structures, a cornerstone reaction in modern organic synthesis.
• Chemical Biology & Probe Development: Utilized in creating molecular probes and labeled compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring specific, high-purity boronic ester derivatives.

Basic Information

Product Name	2-Morpholin-4-Yl-5-(Trifluoromethyl)Benzeneboronic Acid, Pinacol Ester
CAS No.	906352-77-0
Molecular Formula	C₁₇H₂₁BF₃NO₃
Molecular Weight	355.16 g/mol
Synonyms	[2-(Morpholin-4-yl)-5-(trifluoromethyl)phenyl]boronic acid pinacol ester; 2-(4-Morpholinyl)-5-(trifluoromethyl)benzeneboronic acid pinacol ester; 2-Morpholino-5-(trifluoromethyl)phenylboronic acid pinacol ester; Pinacol [2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]boronate; 5-Trifluoromethyl-2-morpholinophenylboronic acid pinacol ester; CAS 906352-77-0; Boronic acid, B-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 2-Morpholin-4-Yl-5-(Trifluoromethyl)Benzeneboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (HPLC)	≥99.0% (High Purity Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.