Description

1H-Indole-1-Carboxylic Acid, 2-Borono-5-[3-(1,3-Dioxolan-2-Yl)Propyl]-, 1-(1,1-Dimethylethyl) Ester is a sophisticated boronic acid ester derivative of indole, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its dual functionality, combining a protected boronic acid group for cross-coupling reactions with an indole scaffold, enabling the construction of complex heterocyclic systems. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in developing novel active ingredients through Suzuki-Miyaura and other palladium-catalyzed coupling methodologies.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology and CNS (Central Nervous System) research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with complex heterocyclic structures.
• Material Science Research: Serves as a precursor for organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura cross-coupling to form carbon-carbon bonds, enabling the modular construction of complex molecules.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological pathways and protein interactions.
• Academic & Process R&D: A valuable reagent for method development and scaling novel synthetic routes in academic and industrial research laboratories.

Basic Information

Item	Details
Product Name	1H-Indole-1-Carboxylic Acid, 2-Borono-5-[3-(1,3-Dioxolan-2-Yl)Propyl]-, 1-(1,1-Dimethylethyl) Ester
CAS No.	906000-55-3
Molecular Formula	C21H30BNO5
Molecular Weight	387.28 g/mol
Synonyms	tert-Butyl 2-borono-5-[3-(1,3-dioxolan-2-yl)propyl]-1H-indole-1-carboxylate; 2-Borono-5-[3-(1,3-dioxolan-2-yl)propyl]-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; Boronic acid, B-[5-[3-(1,3-dioxolan-2-yl)propyl]-1-[[(1,1-dimethylethoxy)carbonyl]-1H-indol-2-yl]-; 906000-55-3; tert-Butyl 2-boron-5-(3-(1,3-dioxolan-2-yl)propyl)-1H-indole-1-carboxylate; Protected Indole Boronic Acid Ester; Indole-1-carboxylic acid, 2-borono-5-[3-(1,3-dioxolan-2-yl)propyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1H-Indole-1-Carboxylic Acid, 2-Borono-5-[3-(1,3-Dioxolan-2-Yl)Propyl]-, 1-(1,1-Dimethylethyl) Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, critical for sensitive cross-coupling reactions. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications to support your R&D and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. For long-term stability, it is recommended to store the product at 2-8°C under an inert atmosphere such as nitrogen or argon to prevent potential degradation of the boronic ester functionality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.