Description

6-Fluoro-7-Methoxyisoquinolin-1(2H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique fluorinated isoquinolinone structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) research. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for developing next-generation therapeutic agents and for process optimization in scale-up campaigns.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of complex drug molecules, especially kinase inhibitors and other targeted therapies.
• Organic Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization due to its fluorinated and methoxylated motifs.
• Research & Development (R&D): Essential for academic and industrial research focused on developing new chemical entities (NCEs) with potential biological activity.
• Agrochemical Research: Potential application as an intermediate in the development of novel herbicides or fungicides, leveraging its heterocyclic core.
• Material Science: Can be investigated as a monomer or functional component in the creation of specialty polymers or organic electronic materials.

Basic Information

Product Name	6-Fluoro-7-Methoxyisoquinolin-1(2H)-One
CAS No.	905994-27-6
Molecular Formula	C₁₀H₈FNO₂
Molecular Weight	193.18 g/mol
Synonyms	1(2H)-Isoquinolinone, 6-fluoro-7-methoxy-; 6-Fluoro-7-methoxy-1,2-dihydroisoquinolin-1-one; 6-Fluoro-7-methoxy-1H-isoquinolin-1-one; 6-Fluoro-7-methoxyisoquinolin-1-ol; 905994-27-6; 6-Fluoro-7-methoxy-1,2-dihydroisoquinolin-1-one; 6-Fluoro-7-methoxyisoquinolin-1(2H)-one
EINECS	Contact for details

Quality Control

Our 6-Fluoro-7-Methoxyisoquinolin-1(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. The container must be kept tightly closed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.