Description

6-Benzofuranol, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 6-Acetate is a high-purity boronic ester derivative, a crucial protected intermediate in modern synthetic organic chemistry. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing benzofuran or complex aryl-aryl bond structures.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific aromatic coupling steps.
• Material Science Research: Serves as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular architecture is critical.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form carbon-carbon bonds between aromatic rings under mild conditions.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new synthetic pathways in both university and corporate research laboratories.

Basic Information

Product Name	6-Benzofuranol, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 6-Acetate
CAS No.	905971-68-8
Molecular Formula	C₁₆H₂₁BO₅
Molecular Weight	304.15 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-benzofuranol 6-acetate; 6-Acetoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran; 6-Hydroxybenzofuran-3-boronic acid pinacol ester acetate; Benzofuran-3-boronic acid, 6-hydroxy-, pinacol ester, 6-acetate; 3-Borono-6-hydroxybenzofuran pinacol ester 6-acetate; 6-Acetyloxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzofuran
EINECS	Contact for details

Quality Control

Our 6-Benzofuranol, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 6-Acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific research or cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and oxidation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.