Description

2-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)-1-Methyl-1H-Indole is a valuable indole-based boronic ester derivative, serving as a key synthetic intermediate in modern organic chemistry. Its primary value lies in its role as a protected boronic acid, offering enhanced stability and handling characteristics for critical cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries engaged in developing novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug candidates, particularly those containing indole scaffolds, via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides that require specific indole-boronate structures.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and conductive polymers, where precise molecular architecture is required.
• Chemical Biology & Probe Development: Acts as a versatile handle for bioconjugation and the creation of molecular probes for diagnostic and research applications.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in organic synthesis and catalysis studies.
• Fine Chemical Production: Serves as a specialized intermediate for the custom synthesis of high-value, low-volume chemicals for various industrial applications.

Basic Information

Product Name	2-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)-1-Methyl-1H-Indole
CAS No.	905966-48-5
Molecular Formula	C14H18BNO2
Molecular Weight	243.11 g/mol
Synonyms	1-Methyl-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-1H-indole; 1-Methylindole-2-boronic acid 5,5-dimethyl-1,3,2-dioxaborinane ester; 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-1-methylindole; 1-Methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole (related pinacol ester); 1-Methyl-1H-indole-2-boronic acid cyclic ester with 2,2-dimethyl-1,3-propanediol; MIDA Boronate Ester Analog; Indole-2-boronic ester derivative
EINECS	Contact for details

Quality Control

Our 2-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)-1-Methyl-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.