Description

4-(Trifluoromethyl)Indoline is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl-substituted indoline scaffold, which imparts desirable properties like enhanced metabolic stability and lipophilicity to target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, as well as by material scientists exploring specialty polymers and electronic chemicals.

Application

• Pharmaceutical Intermediates: A key synthon for the development of drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the CF3 group improves biological activity.
• Material Science: Serves as a precursor for functionalized polymers and liquid crystals with specific optical or electronic properties.
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of electron-transport or host materials for display technologies.
• Chemical Research: A versatile building block for medicinal chemistry, facilitating structure-activity relationship (SAR) studies and library synthesis.
• Fluorine Chemistry: Valuable for introducing the trifluoromethyl group into complex molecular architectures under controlled conditions.

Basic Information

Product Name	4-(Trifluoromethyl)Indoline
CAS No.	905274-07-9
Molecular Formula	C9H8F3N
Molecular Weight	187.16 g/mol
Synonyms	4-(Trifluoromethyl)-2,3-dihydro-1H-indole; 1H-Indole, 2,3-dihydro-4-(trifluoromethyl)-; 4-Trifluoromethylindoline; Indoline, 4-(trifluoromethyl)-; 4-CF3-Indoline
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Indoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We adhere to cGMP principles for pharmaceutical-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.