Description

tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoindoline-2-Carboxyl is a high-purity, protected isoindoline boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in providing a stable, reactive handle for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in constructing isoindoline-based scaffolds for CNS, oncology, and cardiovascular targets.
• Suzuki-Miyaura Cross-Coupling: Enables the formation of carbon-carbon bonds to introduce the isoindoline moiety into complex molecules under mild, palladium-catalyzed conditions.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides requiring specific heterocyclic structures.
• Material Science & OLED Development: Potential precursor for creating organic electronic materials, ligands for catalysts, and emissive layers in display technologies.
• Academic & Contract Research: A valuable reagent for methodology development and library synthesis in academic laboratories and CROs (Contract Research Organizations).
• Peptidomimetics & PROTACs: Facilitates the synthesis of isoindoline-containing peptidomimetics and Proteolysis-Targeting Chimeras (PROTACs) for targeted protein degradation.

Basic Information

Item	Details
Product Name	tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoindoline-2-Carboxyl
CAS No.	905273-91-8
Molecular Formula	C19H28BNO4
Molecular Weight	345.24 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-isoindolinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindoline-2-carboxylate; 2-tert-Butoxycarbonyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindoline; Boc-Protected Isoindoline Boronic Ester; 5-Pinacolboron Isoindoline-2-carboxylic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoindoline-2-Carboxyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with full analytical data are provided to guarantee consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.