Description

1-(Tetrahydropyran-2-Yl)-1H-Pyrazole-5-Boronic Acid Pinacol Ester is a high-purity, protected boronic acid ester derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon for constructing novel heterocyclic scaffolds in active pharmaceutical ingredient (API) development and medicinal chemistry research.
• Agrochemical Synthesis: Used in the creation of advanced crop protection agents and herbicides requiring specific pyrazole-based architectures.
• Material Science Research: Serves as a precursor for synthesizing organic electronic materials, ligands for catalysis, and functional polymers.
• Cross-Coupling Reactions: Specifically designed for use in palladium-catalyzed Suzuki-Miyaura couplings to introduce the pyrazole-tetrahydropyran moiety into target molecules.
• Chemical Library Production: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for screening.
• Academic & R&D Laboratories: A valuable reagent for methodological development and complex molecule synthesis in academic and industrial R&D settings.

Basic Information

Product Name	1-(Tetrahydropyran-2-Yl)-1H-Pyrazole-5-Boronic Acid Pinacol Ester
CAS No.	903550-26-5
Molecular Formula	C14H23BN2O3
Molecular Weight	278.16 g/mol
Synonyms	1-(Oxan-2-yl)-1H-pyrazol-5-ylboronic acid pinacol ester; 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole; 1-THP-1H-Pyrazole-5-Boronic Acid Pinacol Ester; 1-(THP)-Pyrazole-5-Boronate Pinacol Ester; Pyrazole-THP Boronic Ester; 903550-26-5
EINECS	Contact for details

Quality Control

Our 1-(Tetrahydropyran-2-Yl)-1H-Pyrazole-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity building blocks for regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.