Description

1-(2-Trimethylsilanylethoxymethyl)-1H-Pyrazole-5-Boronic Acid Pinacol Ester is a high-value, protected boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic scaffolds. The CAS number for this compound is provided in the table below.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing pyrazole-containing active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Research & Development: Used in the synthesis of novel herbicides, fungicides, and insecticides that incorporate the pyrazole heterocycle.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, including charge-transport layers and emissive materials in OLED devices.
• Ligand & Catalyst Design: Employed in the synthesis of novel N-heterocyclic ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Utilized to create bioconjugates and molecular probes for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-(2-Trimethylsilanylethoxymethyl)-1H-Pyrazole-5-Boronic Acid Pinacol Ester
CAS No.	903550-12-9
Molecular Formula	C16H31BN2O3Si
Molecular Weight	338.33 g/mol
Synonyms	1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazole-5-boronic acid pinacol ester; 1H-Pyrazole-5-boronic acid, 1-[(2-(trimethylsilyl)ethoxy)methyl]-, 1,1-dimethylethyl ester; 1-(SEM)-1H-Pyrazole-5-boronic Acid Pinacol Ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole; Pyrazole-5-boronic acid SEM-protected pinacol ester; SEM-Pyrazole-5-Bpin
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized by NMR (¹H, ¹³C, ¹¹B), HPLC, and mass spectrometry to confirm identity and purity. We adhere to strict in-process controls, and Certificates of Analysis (COA) with detailed chromatographic data are available upon request. Our quality management system supports the needs of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.