Description

5-(Trifluoromethyl)Thiophene-2-Carbaldehyde is a high-purity fluorinated heterocyclic building block, essential for introducing the trifluoromethyl-thiophene moiety into complex molecular architectures. This compound matters because it serves as a versatile and critical intermediate in advanced organic synthesis, enabling the development of novel materials and active compounds with tailored properties. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and material science industries for creating new drug candidates, crop protection agents, and functional organic materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for organic semiconductors, conductive polymers, and liquid crystals, contributing to electronic and optoelectronic device development.
• Cross-Coupling Reactions: The aldehyde functionality makes it an ideal substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Ligand and Catalyst Development: Employed in the synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable compound for studying the effects of fluorine substitution on reactivity and physical properties in heterocyclic chemistry.

Basic Information

Product Name	5-(Trifluoromethyl)Thiophene-2-Carbaldehyde
CAS No.	901767-00-8
Molecular Formula	C6H3F3OS
Molecular Weight	180.15 g/mol
Synonyms	2-Formyl-5-(trifluoromethyl)thiophene; 5-(Trifluoromethyl)-2-thiophenecarboxaldehyde; 5-Trifluoromethylthiophene-2-carboxaldehyde; 2-Thiophenecarboxaldehyde, 5-(trifluoromethyl)-; α-Trifluoromethyl-2-thiophenecarboxaldehyde; Thiophene-2-carbaldehyde, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2-thiophenecarbaldehyde
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Thiophene-2-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.