Description

1-Bromo-5-Chloro-2-Fluoro-4-Methoxybenzene is a high-purity, multi-halogenated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique substitution pattern, which allows for selective and sequential functionalization in complex molecule construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a specific halogenated aromatic core.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the halogen and methoxy groups contribute to biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed to synthesize complex chelating ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry: The presence of fluorine makes it a valuable substrate for further fluorination reactions and the study of fluorine effects in medicinal chemistry.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination due to the bromo substituent.

Basic Information

Product Name	1-Bromo-5-Chloro-2-Fluoro-4-Methoxybenzene
CAS No.	901236-75-7
Molecular Formula	C7H5BrClFO
Molecular Weight	239.47 g/mol
Synonyms	2-Bromo-4-Chloro-5-Fluoroanisole; 4-Bromo-2-Chloro-1-Fluoro-5-Methoxybenzene; Benzene, 1-bromo-5-chloro-2-fluoro-4-methoxy-; 5-Chloro-2-fluoro-4-methoxybromobenzene; 1-Bromo-5-chloro-2-fluoro-4-methoxy-benzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-5-Chloro-2-Fluoro-4-Methoxybenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.