Description

(+/-)-1-Methoxy-4-(trans-2-(Trifluoromethyl)Cyclopropyl)Benzene is a high-value, advanced pharmaceutical intermediate featuring a unique cyclopropyl ring substituted with a trifluoromethyl group. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules where the cyclopropane and trifluoromethyl motifs are used to modulate potency, metabolic stability, and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to explore the impact of the rigid cyclopropane and lipophilic trifluoromethyl group on biological activity.
• Agrochemical Research: Intermediate in the development of new generation pesticides and herbicides with enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science: Potential monomer or additive for specialty polymers where fluorine-containing groups impart unique surface properties.
• Chemical Biology: Used as a probe or tag in biochemical studies due to the distinct properties of the fluorine atoms.

Basic Information

Product Name	(+/-)-1-Methoxy-4-(trans-2-(Trifluoromethyl)Cyclopropyl)Benzene
CAS No.	900779-69-3
Molecular Formula	C11H11F3O
Molecular Weight	216.20 g/mol
Synonyms	1-Methoxy-4-[(1R,2S)-2-(trifluoromethyl)cyclopropyl]benzene (racemic); 4-(trans-2-(Trifluoromethyl)cyclopropyl)anisole; p-Methoxy-trans-α-(trifluoromethyl)cyclopropylbenzene; Anisole, 4-[(1R,2S)-2-(trifluoromethyl)cyclopropyl]-, (±)-; trans-2-(Trifluoromethyl)cyclopropyl phenyl methyl ether; 1-Methoxy-4-(2-(trifluoromethyl)cyclopropyl)benzene (racemic mixture); 4-(2-(Trifluoromethyl)cyclopropyl)anisole
EINECS	Contact for details

Quality Control

Our production of (+/-)-1-Methoxy-4-(trans-2-(Trifluoromethyl)Cyclopropyl)Benzene adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive R&D applications. Each lot is characterized by advanced analytical techniques including GC, HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.