Description

tert-Butyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-8-Azabicyclo[3.2.1]Oct-3-Ene-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester and a rigid bicyclic amine scaffold. This compound is a critical building block for medicinal chemists, enabling efficient Suzuki-Miyaura cross-coupling reactions to construct complex molecular architectures. It is primarily utilized by research and development organizations in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds in medicinal chemistry and process development.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of bifunctional linker molecules for targeted protein degradation platforms.
• Chemical Biology & Probe Synthesis: Enables the creation of molecular probes for studying biological pathways and target engagement.
• Agrochemical Research: Employed in the discovery and development of novel crop protection agents with complex stereochemistry.
• Academic & Contract Research: Essential for synthetic methodology research and custom synthesis projects in academic and CRO laboratories.

Basic Information

Product Name	tert-Butyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-8-Azabicyclo[3.2.1]Oct-3-Ene-8-Carboxylate
CAS No.	900503-08-4
Molecular Formula	C20H34BNO4
Molecular Weight	363.30 g/mol
Synonyms	8-Boc-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene; tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylate; 8-Azabicyclo[3.2.1]oct-3-ene-8-carboxylic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-3-ene-8-carboxylic acid tert-butyl ester; BOC-Protected 3-Boronic Acid Pinacol Ester of 8-Azabicyclo[3.2.1]oct-3-ene
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-8-Azabicyclo[3.2.1]Oct-3-Ene-8-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.