Description

3-(T-Butyldimethylsilyloxy)-4-Methoxyphenylboronic is a high-purity, organoboronic acid derivative featuring a protected phenolic hydroxyl group, making it a valuable synthetic intermediate. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures in advanced chemical synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the efficient production of novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl couplings.
• Material Science Research: Employed in the creation of organic electronic materials, such as those for OLEDs and organic photovoltaics, where precise molecular architecture is critical.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and target engagement.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-(T-Butyldimethylsilyloxy)-4-Methoxyphenylboronic
CAS No.	900152-53-6
Molecular Formula	C₁₃H₂₃BO₄Si
Molecular Weight	282.22 g/mol
Synonyms	3-[(tert-Butyldimethylsilyl)oxy]-4-methoxybenzeneboronic acid; 4-Methoxy-3-[(tert-butyldimethylsilyl)oxy]phenylboronic acid; (3-((tert-Butyldimethylsilyl)oxy)-4-methoxyphenyl)boronic acid; 3-TBDMSO-4-Methoxyphenylboronic Acid; 3-(tert-Butyldimethylsiloxy)-4-methoxyphenylboronic acid; Boronic acid, B-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]-
EINECS	Contact for details

Quality Control

Every batch of 3-(T-Butyldimethylsilyloxy)-4-Methoxyphenylboronic is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our products are characterized by NMR (¹H and ¹³C), HPLC, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.