Description

2-Chloro-1-(8-Hydroxyquinolin-5-Yl)Ethanone is a specialized organic intermediate featuring a reactive chloroacetyl group attached to the 8-hydroxyquinoline scaffold. This molecular architecture makes it a valuable building block for synthesizing more complex heterocyclic compounds and functional materials. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and ligands.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting metal-associated diseases or requiring chelating properties.
• Agrochemical Synthesis: Used in the development of new fungicides, herbicides, or pesticides that leverage the bioactivity of the quinoline moiety.
• Coordination Chemistry & Ligand Synthesis: Serves as a starting material for creating sophisticated chelating ligands used in catalysis, material science, and analytical chemistry.
• Material Science Research: Employed in the development of organic semiconductors, fluorescent sensors, or metal-organic frameworks (MOFs).
• Chemical Research & Development: A versatile synthon for academic and industrial R&D focused on heterocyclic chemistry and structure-activity relationship (SAR) studies.

Basic Information

Product Name	2-Chloro-1-(8-Hydroxyquinolin-5-Yl)Ethanone
CAS No.	99973-51-0
Molecular Formula	C₁₁H₈ClNO₂
Molecular Weight	221.64 g/mol
Synonyms	5-Chloroacetyl-8-hydroxyquinoline; 5-(2-Chloroacetyl)-8-hydroxyquinoline; 2-Chloro-1-(8-hydroxy-5-quinolyl)ethanone; 8-Hydroxy-5-quinolyl chloromethyl ketone; 5-(Chloroacetyl)-8-quinolinol; Ethanone, 2-chloro-1-(8-hydroxy-5-quinolinyl)-; 99973-51-0
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-1-(8-Hydroxyquinolin-5-Yl)Ethanone adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Each lot is fully characterized using modern analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.