Description

Methyl 3 - Bromo - 2,2 - Difluoropropanoate is a high-value fluorinated building block essential for advanced organic synthesis. This compound matters for its unique reactivity profile, combining a bromo substituent with a difluoroacetate moiety, enabling precise molecular construction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, particularly in protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where the difluoromethyl group enhances bioavailability and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent for specialty polymers with tailored surface properties and chemical resistance.
• Fluorination Reagent: Acts as a source of the -CHF2 or -CF2CO- moiety in nucleophilic or radical fluorination reactions.
• Ligand and Catalyst Development: Employed in the synthesis of complex, fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• PET (Positron Emission Tomography) Tracer Precursor: Potential use in the synthesis of fluorine-18 labeled compounds for medical imaging.

Basic Information

Product Name	Methyl 3 - Bromo - 2,2 - Difluoropropanoate
CAS No.	99953-33-0
Molecular Formula	C4H5BrF2O2
Molecular Weight	199.98 g/mol
Synonyms	Methyl 3-bromo-2,2-difluoropropionate; 3-Bromo-2,2-difluoropropionic Acid Methyl Ester; 2,2-Difluoro-3-bromopropanoic Acid Methyl Ester; Methyl 3-Bromo-2,2-difluoropropanoate; Propanoic acid, 3-bromo-2,2-difluoro-, methyl ester; Methyl α,α-Difluoro-β-bromopropionate
EINECS	Contact for details

Quality Control

Our Methyl 3 - Bromo - 2,2 - Difluoropropanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.