Description

2-Fluoro-D-Ristosamine is a fluorinated derivative of the aminoglycoside antibiotic building block, D-ristosamine. This compound is a critical chiral intermediate in the synthesis of novel, potent antibiotics and other bioactive molecules, where the fluorine atom is strategically introduced to enhance metabolic stability and binding affinity. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers focused on developing next-generation antimicrobial agents and complex carbohydrate-based therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the semi-synthesis of novel fluorinated aminoglycoside antibiotics.
• Antimicrobial Research: Used in the development of compounds targeting resistant bacterial strains by modifying sugar moieties.
• Glycobiology Studies: Serves as a building block for synthesizing fluorinated carbohydrate analogs to study enzyme mechanisms and interactions.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the pharmacokinetic properties of lead molecules.
• Process Chemistry: Used in scale-up and route development for the commercial production of advanced antibiotic APIs.

Basic Information

Product Name	2-Fluoro-D-Ristosamine
CAS No.	99773-72-5
Molecular Formula	C7H14FNO4
Molecular Weight	195.19 g/mol
Synonyms	2-Deoxy-2-fluoro-D-ristosamine; D-Ristosamine, 2-fluoro-; (2R,3S,4R,5R)-5-(Aminomethyl)-2-fluoro-3,4-dihydroxytetrahydrofuran; 2-Fluoro-5-(aminomethyl)-3,4-dihydroxytetrahydrofuran; Fluororistosamine; 2-F-D-Ristosamine
EINECS	Contact for details

Quality Control

Our 2-Fluoro-D-Ristosamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.