Description

2-Fluoro-5-Bromobenzyl Bromide is a versatile and highly reactive halogenated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of fluorine and bromine atoms on the aromatic ring, enabling selective functionalization for creating complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for constructing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated and brominated aromatic motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom enhances lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science: Employed in the creation of advanced polymers and liquid crystals, where the benzyl bromide group acts as a reactive site for polymerization or functional group attachment.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies, including Suzuki, Sonogashira, and Buchwald-Hartwig amination couplings.
• Fluorine Chemistry Studies: Utilized as a model compound in studying the effects of fluorine substitution on reaction kinetics and electronic properties in aromatic systems.

Basic Information

Product Name	2-Fluoro-5-Bromobenzyl Bromide
CAS No.	99725-12-9
Molecular Formula	C7H5Br2F
Molecular Weight	267.92 g/mol
Synonyms	1-(Bromomethyl)-2-fluoro-5-bromobenzene; 5-Bromo-2-fluorobenzyl Bromide; (5-Bromo-2-fluorophenyl)methyl Bromide; α-Bromo-5-bromo-2-fluorotoluene; 2-Fluoro-α,5-dibromotoluene; 99725-12-9; 2-Fluoro-5-bromobenzylbromide
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-Bromobenzyl Bromide is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency to meet the rigorous demands of research and scale-up processes. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as identity, assay, and impurity profiles as determined by HPLC, GC, NMR, and other analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.