Description

β-[(E)-Fluoromethylene]-3-Hydroxyphenylalanine is a fluorinated phenylalanine derivative, a specialized non-natural amino acid analog designed for advanced research and development. This compound matters for its unique structural features, incorporating a fluoromethylene group which can significantly alter the electronic, metabolic, and binding properties of peptides and proteins. It is primarily needed by pharmaceutical researchers and fine chemical manufacturers engaged in the synthesis of novel bioactive peptides, enzyme inhibitors, and potential therapeutic agents, particularly in areas like oncology and metabolic disease.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel peptide-based drugs and enzyme inhibitors.
• Proteomics & Biochemistry Research: Used to incorporate fluorine labels into peptides for NMR studies, metabolic stability assays, and protein engineering.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Peptide Synthesis: Employed in solid-phase and solution-phase peptide synthesis to create analogs with enhanced biological activity or stability.
• Chemical Biology Probes: Utilized in the development of activity-based probes and diagnostic agents targeting specific enzymes or pathways.
• Academic Research: Fundamental studies on fluorine biochemistry and the effects of fluorinated amino acids on protein folding and function.

Basic Information

Item	Details
Product Name	β-[(E)-Fluoromethylene]-3-Hydroxyphenylalanine
CAS No.	99630-95-2
Molecular Formula	C10H10FNO3
Molecular Weight	211.19 g/mol
Synonyms	(E)-3-(3-Hydroxyphenyl)-2-(fluoromethylene)propanoic acid; (E)-2-(Fluoromethylene)-3-(3-hydroxyphenyl)propanoic acid; β-(Fluoromethylene)-m-tyrosine; (E)-β-Fluoromethylene-m-tyrosine; F2mTyr; Fluorinated m-Tyrosine Analog; Non-natural Fluorinated Amino Acid
EINECS	Contact for details

Quality Control

Our β-[(E)-Fluoromethylene]-3-Hydroxyphenylalanine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.