Description

1,3-Dioxolane-4-Carboxaldehyde, 2,2,5-Trimethyl-, (4S,5R)- (9Ci) is a high-value, chiral building block characterized by its protected aldehyde functionality and defined stereochemistry. This compound matters for its role as a key intermediate in the synthesis of complex, biologically active molecules, offering precise control over the final product's three-dimensional structure. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for applications in asymmetric synthesis and the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the asymmetric synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Catalysis Research: Used as a starting material or ligand precursor in the development of new stereoselective catalytic reactions.
• Natural Product Synthesis: Serves as a building block for constructing complex natural products with defined stereocenters.
• Agrochemical Development: Employed in the research and synthesis of chiral pesticides and herbicides where specific stereoisomers exhibit enhanced activity.
• Flavor & Fragrance Chemistry: Potential intermediate for creating stereochemically defined aroma chemicals and flavor compounds.
• Material Science Research: Can be utilized in the synthesis of chiral monomers for advanced polymeric materials.

Basic Information

Item	Detail
Product Name	1,3-Dioxolane-4-Carboxaldehyde, 2,2,5-Trimethyl-, (4S,5R)- (9Ci)
CAS No.	99603-55-1
Molecular Formula	C8H14O3
Molecular Weight	158.20 g/mol
Synonyms	(4S,5R)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxaldehyde; (4S-cis)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxaldehyde; (4S,5R)-2,2,5-Trimethyl-1,3-dioxolane-4-carbaldehyde; 2,2,5-Trimethyl-1,3-dioxolane-4-carboxaldehyde, (4S,5R)-; (4S,5R)-2,2,5-Trimethyl-[1,3]dioxolane-4-carbaldehyde; (4S,5R)-TMDC; Chiral TMDC aldehyde.
EINECS	Contact for details

Quality Control

Our 1,3-Dioxolane-4-Carboxaldehyde, 2,2,5-Trimethyl-, (4S,5R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full specification data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.