Description

Methyl 2,2-Difluoro-3-Methoxypropionate is a high-purity fluorinated building block essential for advanced organic synthesis. This compound is valued for its unique difluoromethylene and methoxy ester functional groups, which are critical for modulating the physicochemical properties of target molecules. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for introducing fluorine atoms into drug candidates to enhance metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the difluoromethylene group can improve efficacy and environmental profile.
• Material Science: Serves as a monomer or precursor for specialty polymers and coatings with tailored surface properties and chemical resistance.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated components for display materials and dielectric fluids.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, nucleophilic substitutions, and other transformations to construct complex molecular architectures.
• Research & Development: A valuable reagent for medicinal chemistry programs and process chemistry optimization in both academic and industrial settings.

Basic Information

Product Name	Methyl 2,2-Difluoro-3-Methoxypropionate
CAS No.	99497-39-9
Molecular Formula	C6H10F2O3
Molecular Weight	168.14 g/mol
Synonyms	Methyl 3-Methoxy-2,2-difluoropropionate; 2,2-Difluoro-3-methoxypropionic Acid Methyl Ester; Methyl 2,2-Difluoro-3-methoxypropanoate; 3-Methoxy-2,2-difluoropropionic Acid Methyl Ester; Methyl α,α-Difluoro-β-methoxypropionate; Propanoic acid, 2,2-difluoro-3-methoxy-, methyl ester; Difluoromethoxymethyl Acetate Methyl Ester (common name)
EINECS	Contact for details

Quality Control

Our Methyl 2,2-Difluoro-3-Methoxypropionate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including GC/HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent quality for your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.380 - 1.390
Density (20°C)	1.20 - 1.30 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.