Description

6-Fluorochromane-2-Carboxylic Acid is a fluorinated chromane derivative that serves as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in the unique combination of the chromane scaffold and a carboxylic acid functional group, which can be readily modified for structure-activity relationship (SAR) studies. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly in central nervous system (CNS) and cardiovascular drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates targeting neurological and cardiovascular diseases.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging the bioactivity of the fluorinated chromane structure.
• Chemical Biology Probe: Serves as a scaffold for designing molecular probes to study enzyme function and biological pathways.
• Material Science Precursor: Can be utilized in the synthesis of advanced organic materials and liquid crystals.
• Asymmetric Catalysis Ligand Precursor: The chiral center makes it a candidate for derivatization into novel ligands for catalytic applications.

Basic Information

Product Name	6-Fluorochromane-2-Carboxylic Acid
CAS No.	99199-60-7
Molecular Formula	C10H9FO3
Molecular Weight	196.18 g/mol
Synonyms	6-Fluorochroman-2-carboxylic acid; 2-Chromancarboxylic acid, 6-fluoro-; 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid; 6-Fluoro-2-chromancarboxylic acid; 6-Fluorodihydrocoumarin-2-carboxylic acid; 6-Fluoro-3,4-dihydrocoumarin-2-carboxylic acid; (2R)-6-Fluorochromane-2-carboxylic acid (enantiomer); (2S)-6-Fluorochromane-2-carboxylic acid (enantiomer)
EINECS	Contact for details

Quality Control

Our 6-Fluorochromane-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and chiral integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grades)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.