Description

4,4,4-Trifluorobut-2-Ynal (CAS NO 99048-75-6) is a highly versatile fluorinated alkyne building block, prized for its unique trifluoromethyl-substituted propargylic aldehyde structure. This compound is critical for introducing the trifluoromethyl group into complex molecules, a key strategy for modulating their lipophilicity, metabolic stability, and binding affinity. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in the development of enzyme inhibitors, receptor modulators, and bioactive molecules where the CF3 group is desired.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorinated moiety can improve biological activity and environmental persistence profiles.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and other specialty materials that benefit from the incorporation of fluorine atoms.
• Organic Synthesis Building Block: Employed in click chemistry, cycloaddition reactions, and other catalytic processes to construct complex heterocycles and carbon frameworks.
• Fluorine Chemistry Research: An important reagent for academic and industrial laboratories exploring new methodologies for C–CF3 bond formation and fluorinated molecule construction.

Basic Information

Product Name	4,4,4-Trifluorobut-2-Ynal
CAS No.	99048-75-6
Molecular Formula	C4H3F3O
Molecular Weight	124.06 g/mol
Synonyms	4,4,4-Trifluorobut-2-ynal; 4,4,4-Trifluorobut-2-yn-1-al; 3,3,3-Trifluoropropiolaldehyde; 4,4,4-Trifluoro-2-butynal; 99048-75-6; But-2-ynal, 4,4,4-trifluoro-; Trifluoromethyl propargyl aldehyde
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluorobut-2-Ynal is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Due to its highly volatile and easily oxidized nature, it is recommended to store at 2-8°C for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.