Description

n-Butane-2-Boronic Acid (1S,2S,3R,5S)-(+)-2,3-Pinanediol Ester is a high-purity, chiral boronic ester derivative, widely recognized for its role as a key synthetic intermediate in asymmetric synthesis. Its primary value lies in its ability to act as a stable, enantiomerically pure boronate reagent for Suzuki-Miyaura cross-coupling reactions, enabling the construction of complex, stereodefined molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in their synthetic routes.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS therapeutic areas.
• Asymmetric Synthesis: Employed in stereoselective Suzuki-Miyaura cross-coupling reactions to create carbon-carbon bonds with high enantiomeric purity.
• Agrochemical Research: Used in the development of novel, enantiomerically pure pesticides and herbicides with improved efficacy and environmental profiles.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organometallic catalysts used in homogeneous catalysis.
• Advanced Material Synthesis: A key reagent in the preparation of chiral polymers, liquid crystals, and organic electronic materials.
• Academic & Process R&D: A valuable tool for methodological development and scale-up studies in organic and medicinal chemistry laboratories.

Basic Information

Product Name	n-Butane-2-Boronic Acid (1S,2S,3R,5S)-(+)-2,3-Pinanediol Ester
CAS No.	98541-36-7
Molecular Formula	C₁₄H₂₅BO₂
Molecular Weight	236.16 g/mol
Synonyms	(+)-Pinanediol 2-Butylboronate; (1S,2S,3R,5S)-Pinanediol 2-Butylboronate; 2-Butyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (Pinanediol ester); (1S,2S,3R,5S)-2-(2-Butyl-1,3,2-dioxaborolan-2-yl)-2,3-pinanediol; 2-Butylboronic Acid Pinanediol Ester; n-Butylboronic Acid (+)-Pinanediol Ester; B-Butyl-9-borabicyclo[3.3.1]nonane (Pinanediol protected); (S,S,R,S)-2,3-Pinanediol n-Butylboronate
EINECS	Contact for details

Quality Control

Our n-Butane-2-Boronic Acid (1S,2S,3R,5S)-(+)-2,3-Pinanediol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and GC analysis, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.