Description

Proline, 4-(1-Propenyl)- (9Ci) is a specialized proline derivative characterized by a propenyl substituent at the 4-position of the pyrrolidine ring. This structural modification makes it a valuable non-proteinogenic amino acid analog and a versatile chiral building block for advanced organic synthesis. It is primarily sought by research institutions and industrial R&D departments engaged in pharmaceutical development, agrochemical research, and the synthesis of complex natural products. Its unique stereochemistry and functional group offer significant potential for creating novel bioactive compounds and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and plant growth regulators that require specific stereochemical configurations for optimal activity.
• Peptidomimetics & Bioactive Molecule Design: Acts as a crucial component for constructing peptidomimetics and other constrained peptide analogs to enhance metabolic stability and binding affinity in drug discovery.
• Asymmetric Catalysis Ligand Precursor: Provides a scaffold for developing novel chiral ligands and organocatalysts used in enantioselective synthesis.
• Fine Chemical and Flavor/Fragrance Intermediate: Employed in the synthesis of complex aroma chemicals and other high-value specialty fine chemicals.
• Academic & Institutional Research: Utilized in chemical biology and medicinal chemistry research to study enzyme-substrate interactions and structure-activity relationships (SAR).

Basic Information

Product Name	Proline, 4-(1-Propenyl)- (9Ci)
CAS No.	98426-31-4
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	4-(Prop-1-en-1-yl)-L-proline; 4-(1-Propenyl)proline; (S)-4-(Prop-1-en-1-yl)pyrrolidine-2-carboxylic acid; 4-Allylidene-proline; L-4-(1-Propenyl)proline; Non-proteinogenic amino acid derivative; Chiral proline analog
EINECS	Contact for details

Quality Control

Our Proline, 4-(1-Propenyl)- (9Ci) is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets rigorous research and development standards. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.