Description

4'-Amino-3'-Chloro-5'-(Trifluoromethyl)Acetophenon is a high-purity, multi-functional aromatic ketone building block distinguished by its trifluoromethyl and chloro-amino substitution pattern. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and organic electronic materials due to its electron-withdrawing substituents.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses serving the life sciences sector.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	4'-Amino-3'-Chloro-5'-(Trifluoromethyl)Acetophenon
CAS No.	97760-76-4
Molecular Formula	C9H7ClF3NO
Molecular Weight	237.61 g/mol
Synonyms	1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)ethanone; 3'-Chloro-4'-amino-5'-(trifluoromethyl)acetophenone; 4-Amino-3-chloro-α,α,α-trifluoroacetophenone; 4-Amino-3-chloro-α,α,α-trifluoroacetophenone; 1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]ethan-1-one; Acetophenone, 4'-amino-3'-chloro-5'-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4'-Amino-3'-Chloro-5'-(Trifluoromethyl)Acetophenon is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.