Description

4-Fluoro-3-Hydroxy-1(3H)-Isobenzofuranone is a specialized fluorinated isobenzofuranone derivative, serving as a crucial high-purity building block in advanced organic synthesis. Its unique molecular structure, featuring both a fluorine atom and a hydroxyl group on the aromatic lactone core, makes it a valuable precursor for developing novel pharmaceutical intermediates and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine moiety enhances bioactivity and stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and advanced organic materials.
• Ligand and Catalyst Development: Utilized in organometallic chemistry to create novel ligands for catalytic systems.
• Fluorine Chemistry Studies: A standard compound for academic and industrial research into the effects of fluorine substitution on lactone reactivity and properties.
• Dye and Pigment Intermediate: Potential precursor for synthesizing fluorinated chromophores and functional dyes.

Basic Information

Product Name	4-Fluoro-3-Hydroxy-1(3H)-Isobenzofuranone
CAS No.	97711-49-4
Molecular Formula	C8H5FO3
Molecular Weight	168.12 g/mol
Synonyms	3-Hydroxy-4-fluoroisobenzofuran-1-one; 4-Fluoro-3-hydroxyphthalide; 4-Fluoro-3-hydroxy-1(3H)-isobenzofuranone; 97711-49-4; 3-Hydroxy-4-fluoro-1(3H)-isobenzofuranone; 4-Fluoro-3-hydroxy-2-benzofuran-1(3H)-one; Fluorohydroxyphthalide
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Hydroxy-1(3H)-Isobenzofuranone is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.