Description

D-Glutamic Acid, 3-Fluoro-, (3R)-Rel- (9Ci) is a fluorinated derivative of the non-proteinogenic D-glutamic acid, characterized by a fluorine atom at the 3-position and a specific (3R) relative stereochemistry. This compound is a high-value chiral building block of significant interest in advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists working on novel therapeutics, particularly in the areas of enzyme inhibitors, prodrug design, and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and other enzyme-targeted drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of fluorination on peptide backbone properties, bioavailability, and metabolic stability.
• Prodrug Development: Serves as a specialized component in the design of prodrugs, leveraging the glutamic acid moiety for enhanced solubility or targeted activation.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme mechanisms, particularly those involving glutamic acid-specific enzymes, where fluorine acts as a isosteric probe.
• Peptidomimetics: Incorporated into synthetic peptides and peptidomimetics to confer resistance to enzymatic degradation and modulate physicochemical properties.

Basic Information

Product Name	D-Glutamic Acid, 3-Fluoro-, (3R)-Rel- (9Ci)
CAS No.	97550-64-6
Molecular Formula	C5H8FNO4
Molecular Weight	165.12 g/mol
Synonyms	(3R)-3-Fluoro-D-glutamic Acid; (R)-3-Fluoroglutamic Acid; D-3-Fluoroglutamic Acid; 3-Fluoro-D-glutamate; (3R)-rel-3-Fluoro-D-glutamic Acid; (R)-3-Fluoro-D-glutamic Acid; 3-Fluoro-(3R)-D-glutamic Acid; (3R)-3-Fluoroglutamic Acid
EINECS	Contact for details

Quality Control

Our D-Glutamic Acid, 3-Fluoro-, (3R)-Rel- (9Ci) is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.