Description

Proline, 3-Fluoro-5-Oxo-, Methyl Ester, cis- (9Ci) is a fluorinated proline derivative, a high-value chiral building block essential for advanced organic synthesis. This compound is particularly significant for introducing conformational constraints and fluorine atoms into peptide backbones, which can dramatically alter biological activity and metabolic stability. It is a critical intermediate for pharmaceutical researchers and fine chemical manufacturers developing novel peptide-based therapeutics, protease inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in oncology, neurology, and antiviral therapies.
• Peptidomimetics & Constrained Peptides: Used to synthesize conformationally restricted peptides, enhancing their receptor selectivity, potency, and resistance to enzymatic degradation.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors of various proteases (e.g., DPP-4, HCV NS3/4A).
• Chemical Biology & Probe Design: Employed in creating activity-based probes and labeled compounds for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Potential intermediate for developing new generation pesticides and herbicides with improved efficacy.
• Material Science: Exploration into fluorinated amino acids for creating specialized polymers and biomaterials with unique properties.

Basic Information

Product Name	Proline, 3-Fluoro-5-Oxo-, Methyl Ester, cis- (9Ci)
CAS No.	97315-82-7
Molecular Formula	C7H10FNO3
Molecular Weight	175.16 g/mol
Synonyms	(2S,3R)-3-Fluoro-5-oxopyrrolidine-2-carboxylic acid methyl ester; Methyl (2S,3R)-3-fluoro-5-oxopyrrolidine-2-carboxylate; cis-3-Fluoro-5-oxoproline methyl ester; (3R)-3-Fluoro-5-oxo-L-proline methyl ester; 3-Fluoro-5-oxo-L-proline methyl ester (cis); Methyl 3-fluoro-5-oxo-L-prolinate; L-Proline, 3-fluoro-5-oxo-, methyl ester, (3R)-
EINECS	Contact for details

Quality Control

Our Proline, 3-Fluoro-5-Oxo-, Methyl Ester, cis- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D and scale-up. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral excess, NMR, and MS data is supplied with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.