Description

L-Glutamic Acid, 3-Fluoro-, Threo- (9Ci) is a fluorinated derivative of the essential amino acid L-glutamic acid, featuring a fluorine atom at the 3-position in the threo configuration. This specific structural modification makes it a valuable chiral building block and intermediate for advanced pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel bioactive compounds, including potential drug candidates and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly in neurological and metabolic disorder research.
• Protease & Enzyme Inhibitor Development: Used to create fluorinated peptide analogs that act as potent inhibitors for various enzymes like glutamic acid-specific proteases.
• Agrochemical Research: Serves as a building block for developing new herbicides or plant growth regulators with modified activity profiles.
• Biochemical Tool Compound: Employed in metabolic pathway studies to investigate the role of fluorinated amino acids in biological systems.
• Peptide Chemistry: Incorporated into custom peptides to study the effects of fluorination on peptide structure, stability, and receptor binding affinity.
• Radiopharmaceutical Precursor: Potential precursor for F-18 labeled compounds used in Positron Emission Tomography (PET) imaging, given the presence of fluorine.

Basic Information

Product Name	L-Glutamic Acid, 3-Fluoro-, Threo- (9Ci)
CAS No.	97315-77-0
Molecular Formula	C5H8FNO4
Molecular Weight	165.12 g/mol
Synonyms	(2S,3S)-3-Fluoroglutamic Acid; L-threo-3-Fluoroglutamic Acid; (2S,3S)-3-Fluoro-L-glutamic Acid; 3-Fluoro-L-glutamic Acid; 3-Fluoroglutamic Acid; F-Glu; 3-F-Glu; FLUORO-DL-GLUTAMIC ACID (isomeric mixture reference)
EINECS	Contact for details

Quality Control

Our L-Glutamic Acid, 3-Fluoro-, Threo- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results for parameters including assay, enantiomeric excess, and impurity profiles. Our quality commitment supports applications requiring high-purity research chemicals, and we can discuss custom specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee (Threo isomer)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.