Description

3-tert-Butyldimethylsiloxy-4-Methoxybenzaldehyde is a key protected aldehyde intermediate used in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought after by fine chemical manufacturers and R&D laboratories engaged in the synthesis of active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Organic Synthesis Reagent: Used in palladium-catalyzed cross-coupling reactions, such as Suzuki or Heck reactions, to introduce functionalized aromatic units.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group protects the phenolic hydroxyl during synthetic sequences, allowing for selective reactions elsewhere on the molecule.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis.
• Material Science Research: Employed in the development of organic electronic materials and advanced polymers requiring specific aromatic aldehydes.
• Agrochemical Synthesis: Intermediate in the production of certain high-performance pesticides and herbicides.

Basic Information

Item	Details
Product Name	3-tert-Butyldimethylsiloxy-4-Methoxybenzaldehyde
CAS No.	97315-18-9
Molecular Formula	C14H22O3Si
Molecular Weight	266.41 g/mol
Synonyms	4-Methoxy-3-[(tert-butyldimethylsilyl)oxy]benzaldehyde; 3-[(tert-Butyldimethylsilyl)oxy]-4-methoxybenzaldehyde; 3-(tert-Butyldimethylsiloxy)-4-methoxybenzaldehyde; 4-Methoxy-3-(TBDMS-oxy)benzaldehyde; TBDMS-protected Vanillin Derivative; 3-TBDMSO-4-Methoxybenzaldehyde
EINECS	Contact for details

Quality Control

Our 3-tert-Butyldimethylsiloxy-4-Methoxybenzaldehyde is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available for every shipment. We adhere to cGMP standards where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to moisture during use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.