Description

3-(4-(Iodomethyl)Phenyl)-3-(Trifluoromethyl)-3H-Diazirine is a highly specialized photoaffinity labeling reagent, a critical tool in chemical biology and pharmaceutical research. Its core value lies in its ability to form covalent bonds with target biomolecules upon UV light activation, enabling the study of protein-ligand interactions and binding sites. This compound is essential for researchers in drug discovery, proteomics, and structural biology who require precise molecular mapping tools.

Application

• Photoaffinity Labeling (PAL): Covalent cross-linking agent for identifying and characterizing protein-ligand interactions in drug discovery pipelines.
• Chemical Proteomics: Used in activity-based protein profiling (ABPP) to identify enzyme active sites and map protein function.
• Bioconjugation & Probe Development: Serves as a key intermediate for synthesizing advanced molecular probes and diagnostic agents.
• Structural Biology Studies: Aids in the elucidation of three-dimensional protein structures and binding mechanisms.
• Material Science Surface Modification: Potential use in creating functionalized surfaces with specific reactive groups for sensor development.
• Radiolabeling Precursor: The iodine moiety provides a handle for potential incorporation of radioactive isotopes for tracer studies.

Basic Information

Product Name	3-(4-(Iodomethyl)Phenyl)-3-(Trifluoromethyl)-3H-Diazirine
CAS No.	95758-92-2
Molecular Formula	C9H6F3IN2
Molecular Weight	338.06 g/mol
Synonyms	4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)benzyl iodide; 3-(4-(Iodomethyl)phenyl)-3-(trifluoromethyl)diaziridine; TID; 3-Trifluoromethyl-3-(p-iodophenyl)diazirine; Photoaffinity Labeling Reagent TID; 3-[4-(Iodomethyl)phenyl]-3-(trifluoromethyl)-3H-diazirine; 3-(p-Iodobenzyl)-3-(trifluoromethyl)diazirine
EINECS	Contact for details

Quality Control

Our 3-(4-(Iodomethyl)Phenyl)-3-(Trifluoromethyl)-3H-Diazirine is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, critical for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We adhere to relevant industry standards for fine chemical production to guarantee reliable performance in your experimental workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as indicated on the label or Certificate of Analysis. For prolonged storage, consider storage under an inert atmosphere such as argon or nitrogen to maximize stability. Keep the container in a dry, well-ventilated place.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in common organic solvents (DMSO, DMF, Acetone)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.