Description

3H-Diazirine is a highly versatile and reactive heterocyclic compound, serving as a crucial photoaffinity labeling reagent and a valuable precursor in organic synthesis. Its ability to generate highly reactive carbenes upon photolysis makes it indispensable for probing biomolecular interactions and constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular tagging and synthesis are required.

Application

• Photoaffinity Labeling (PAL): A key reagent for mapping protein-ligand binding sites and studying biological pathways through covalent crosslinking upon UV light activation.
• Carbene Chemistry: Serves as a clean, in-situ source of carbenes for cyclopropanation, C-H insertion, and other valuable carbon-carbon bond-forming reactions.
• Bioconjugation & Probe Development: Used to create stable, covalent linkages for attaching fluorescent tags, affinity handles, or other reporter molecules to biomolecules.
• Polymer & Surface Modification: Enables the functionalization of polymer chains and material surfaces via carbene insertion, altering physical and chemical properties.
• Pharmaceutical Intermediate: Acts as a building block in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Employed in the development of novel pesticides and herbicides by studying their interaction with biological targets.
• Materials Science: Facilitates the development of novel crosslinked polymers and smart materials with tailored functionalities.

Basic Information

Product Name	3H-Diazirine
CAS No.	157-22-2
Molecular Formula	C2H2N2
Molecular Weight	54.05 g/mol
Synonyms	Diaziridine, 3H-; Diazacyclopropene; Diazirine; 3H-Diazacyclopropene; Diaziridine; 1,2-Didehydrodiaziridine; 1,2-Diazacyclopropene; 3H-Diazirine
EINECS	205-857-6

Quality Control

Our 3H-Diazirine is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive research and synthesis applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and advanced research customers globally.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and easily oxidized nature, this product should be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures between 2°C and 8°C. The container must be kept in a cool, dry, well-ventilated place away from heat and ignition sources. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress and pressure changes.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.