Description

4-Amino-3-Chloro-5-(Trifluoromethyl)Benzaldehyde is a high-value trifluoromethylated aromatic aldehyde building block, distinguished by its unique combination of amino, chloro, and aldehyde functional groups. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the trifluoromethyl group imparts desirable properties like enhanced metabolic stability and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers with tailored electronic properties.
• Fluorescent Probe and Dye Chemistry: Acts as a starting material for synthesizing fluorophores and molecular probes used in bioimaging and diagnostics.
• Custom Synthesis and Contract Manufacturing: A vital building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	4-Amino-3-Chloro-5-(Trifluoromethyl)Benzaldehyde
CAS No.	95656-51-2
Molecular Formula	C8H5ClF3NO
Molecular Weight	223.58 g/mol
Synonyms	3-Chloro-4-amino-5-(trifluoromethyl)benzaldehyde; 5-(Trifluoromethyl)-3-chloro-4-aminobenzaldehyde; 4-Amino-3-chloro-α,α,α-trifluoro-m-tolualdehyde; 2-Chloro-5-formyl-4-(trifluoromethyl)aniline; Benzaldehyde, 4-amino-3-chloro-5-(trifluoromethyl)-; 95656-51-2
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-3-Chloro-5-(Trifluoromethyl)Benzaldehyde is manufactured under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.