Description

2-Deoxy-2,2-Difluoro-D-Threo-Pentonic Acid γ-Lactone is a high-purity fluorinated sugar derivative and a critical chiral building block in organic synthesis. Its primary commercial value lies in its role as a key intermediate for the production of nucleoside analogs, which are essential in antiviral and anticancer pharmaceuticals. This compound is particularly vital for manufacturers in the pharmaceutical and fine chemical industries requiring precise, high-quality intermediates for complex API synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside-based antiviral drugs, including Gemcitabine and related chemotherapeutic agents.
• Anticancer Drug Synthesis: Serves as a fundamental chiral scaffold for developing novel oncology treatments and targeted therapies.
• Antiviral Drug Development: Used in the research and manufacturing of potent antiviral compounds that inhibit viral replication.
• Fine Chemical Synthesis: Employed as a specialized building block for creating complex, fluorinated organic molecules with specific biological activity.
• Biochemical Research: Utilized in academic and industrial R&D for studying enzyme mechanisms and developing new therapeutic pathways.
• Process Chemistry: Applied in scale-up and optimization of manufacturing routes for high-value active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-Deoxy-2,2-Difluoro-D-Threo-Pentonic Acid γ-Lactone
CAS No.	95058-77-8
Molecular Formula	C5H6F2O4
Molecular Weight	168.10 g/mol
Synonyms	2-Deoxy-2,2-difluoro-D-erythro-pentono-1,4-lactone; D-Glycero-D-gulo-Heptono-1,4-lactone, 2-deoxy-2,2-difluoro-; Gemcitabine Intermediate; 2-Deoxy-2,2-difluoropentonic acid γ-lactone; DFDL; Difluorolactone; (3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3,4-dihydro-2H-pyran-2-one, 3,4-dideoxy-3,3-difluoro-
EINECS	Contact for details

Quality Control

Our 2-Deoxy-2,2-Difluoro-D-Threo-Pentonic Acid γ-Lactone is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical synthesis. Each batch is subjected to comprehensive analytical testing, including chiral purity verification and stringent impurity profiling via HPLC. A Certificate of Analysis (COA) detailing identity, purity (typically ≥98.0%), and specific tests is provided with every shipment to ensure traceability and compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.