Description

Proline, 4-Fluoro-5-Oxo-, Methyl Ester, cis- (9Ci) is a high-purity, fluorinated proline derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its unique structure, featuring a fluorine atom and a keto-ester group on the proline backbone, makes it invaluable for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, peptide mimetics, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in protease inhibitor and peptide-based therapeutic programs.
• Medicinal Chemistry: Used to introduce fluorine and constrained ring systems into lead compounds to enhance metabolic stability, bioavailability, and binding affinity.
• Peptidomimetics: Serves as a non-natural amino acid analog for constructing conformationally restricted peptides with improved pharmacological profiles.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, or plant growth regulators that require fluorinated bioactive components.
• Chemical Biology Probes: Useful for labeling studies or as a component in the design of enzyme inhibitors and receptor ligands for mechanistic studies.
• Academic & Industrial R&D: A valuable reagent for methodological development in asymmetric synthesis and fluorine chemistry within research laboratories.

Basic Information

Product Name	Proline, 4-Fluoro-5-Oxo-, Methyl Ester, cis- (9Ci)
CAS No.	95048-76-3
Molecular Formula	C7H10FNO3
Molecular Weight	175.16 g/mol
Synonyms	cis-4-Fluoro-5-oxoproline methyl ester; Methyl cis-4-fluoro-5-oxo-L-prolinate; (2S,4S)-4-Fluoro-5-oxopyrrolidine-2-carboxylic acid methyl ester; 4-Fluoro-5-oxo-L-proline methyl ester; L-Proline, 4-fluoro-5-oxo-, methyl ester, (4S)-; Fluoroproline derivative; 95048-76-3; Methyl 4-fluoro-5-oxoproline-2-carboxylate
EINECS	Contact for details

Quality Control

Every batch of Proline, 4-Fluoro-5-Oxo-, Methyl Ester, cis- (9Ci) is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.