Description

(3R)-3Aβ,4,5,6,6Aβ,7,8,9,9Aβ,9Bα-Decahydro-3β,8β-Dihydroxy-3-(Hydroxymethyl)-6,9-Bis(Methylene)Azuleno[4,5-B]Furan-2(3H)-One is a high-purity, complex sesquiterpene lactone derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound matters as a sophisticated chiral building block and a potential precursor for the development of novel bioactive molecules with anti-inflammatory or cytotoxic properties. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, natural product synthesis, and the exploration of new chemical entities for therapeutic applications.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel drug candidates, particularly in oncology and immunology.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Natural Product Synthesis: Acts as a critical intermediate in the total or semi-synthesis of complex natural products within the sesquiterpene family.
• Biochemical Probe Development: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Advanced Organic Synthesis: Employed in methodological development for stereoselective reactions and the construction of complex polycyclic frameworks.
• Reference Standard: Provides a high-purity analytical standard for quality control and method validation in research and development laboratories.

Basic Information

Product Name	(3R)-3Aβ,4,5,6,6Aβ,7,8,9,9Aβ,9Bα-Decahydro-3β,8β-Dihydroxy-3-(Hydroxymethyl)-6,9-Bis(Methylene)Azuleno[4,5-B]Furan-2(3H)-One
CAS No.	94410-23-8
Molecular Formula	C15H18O5
Molecular Weight	278.30 g/mol
Synonyms	Alantolactone derivative; (3R)-3a,4,5,6,6a,7,8,9,9a,9b-Decahydro-3,8-dihydroxy-3-(hydroxymethyl)-6,9-bis(methylene)azuleno[4,5-b]furan-2(3H)-one; Isoalantolactone analog; 6,9-Bis(methylene)azuleno[4,5-b]furan-2(3H)-one derivative; Sesquiterpene lactone intermediate; CAS 94410-23-8
EINECS	Contact for details

Quality Control

Our (3R)-3Aβ,4,5,6,6Aβ,7,8,9,9Aβ,9Bα-Decahydro-3β,8β-Dihydroxy-3-(Hydroxymethyl)-6,9-Bis(Methylene)Azuleno[4,5-B]Furan-2(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound may be sensitive to prolonged exposure to heat, moisture, and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.