Description

.Alpha.,Alpha,α-Trifluoro-2-(2-Iodoethyl)Toluene is a specialized fluorinated and iodinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a reactive iodoethyl side chain with a trifluoromethylated aromatic core, enabling precise chemical modifications. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the development of new active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, including potential enzyme inhibitors and receptor modulators.
• Agrochemical Research: Used in creating novel fluorinated pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Material Science: Serves as a precursor for specialty polymers and liquid crystals, leveraging its halogenated structure for specific electronic or optical properties.
• Cross-Coupling Reactions: The iodoethyl moiety acts as a versatile handle for palladium-catalyzed cross-coupling (e.g., Heck, Suzuki, Sonogashira) to form new carbon-carbon bonds.
• Fluorine Chemistry: An essential building block for introducing the trifluoromethyl group into more complex molecular frameworks.
• Radiolabeling Precursor: The iodine atom provides a potential site for isotopic labeling (e.g., with I-125) for tracer studies in biological and chemical research.

Basic Information

Product Name	.Alpha.,Alpha,α-Trifluoro-2-(2-Iodoethyl)Toluene
CAS No.	94022-98-7
Molecular Formula	C9H8F3I
Molecular Weight	300.06 g/mol
Synonyms	2-(2-Iodoethyl)-α,α,α-trifluorotoluene; 1-(2-Iodoethyl)-2-(trifluoromethyl)benzene; α,α,α-Trifluoro-2-(2-iodoethyl)toluene; Benzene, 1-(2-iodoethyl)-2-(trifluoromethyl)-; (2-(Trifluoromethyl)phenyl)ethyl iodide; 2-(2-Iodoethyl)benzotrifluoride; Iodotrifluoroethyltoluene; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our .Alpha.,Alpha,α-Trifluoro-2-(2-Iodoethyl)Toluene is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including chromatographic purity assays and structural confirmation. Certificates of Analysis (COA) detailing specific test results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to the light-sensitive and potentially moisture-sensitive nature of iodinated compounds, containers should be kept sealed under an inert atmosphere when not in use for extended periods.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.