Description

n-Nitrosodi-n-Propyl-D14-Amine is a deuterium-labeled isotopologue of the nitrosamine compound N-Nitrosodi-n-propylamine. This stable isotope-labeled standard is essential for analytical quantification and method development, providing unmatched accuracy in trace analysis. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, environmental, and food safety sectors requiring precise internal standards for mass spectrometry.

Application

• Internal Standard for Mass Spectrometry (MS): Primary use as a quantitative internal standard in GC-MS or LC-MS/MS analysis for its non-labeled counterpart.
• Pharmaceutical Impurity Testing: Used in the accurate quantification of nitrosamine genotoxic impurities (GTIs) in active pharmaceutical ingredients (APIs) and drug products to ensure compliance with regulatory limits (e.g., ICH M7, EMA, FDA).
• Environmental and Food Safety Analysis: Enables precise monitoring of N-Nitrosodi-n-propylamine contamination in water, soil, and food products like cured meats.
• Metabolic and Pharmacokinetic Studies: Serves as a tracer in research investigating the absorption, distribution, metabolism, and excretion (ADME) of nitrosamines.
• Method Development and Validation: Critical for developing, optimizing, and validating highly sensitive and specific analytical methods for nitrosamine detection.
• Quality Control and Assurance: Ensures the reliability and accuracy of testing protocols in contract research organizations (CROs) and analytical testing laboratories.

Basic Information

Product Name	n-Nitrosodi-n-Propyl-D14-Amine
CAS No.	93951-96-3
Molecular Formula	C6D14N2O
Molecular Weight	146.27 g/mol
Synonyms	N-Nitrosodi-n-propylamine-d14; N-Nitrosodi-n-propyl-d14-amine; NDIPA-d14; D14-NDPA; N-Nitroso-di-n-propylamine (perdeuterated); N-Nitrosodipropylamine-d14; Deuterated N-Nitrosodipropylamine; Perdeuterated N-Nitrosodi-n-propylamine
EINECS	Contact for details

Quality Control

Our deuterated standards are produced and handled under strict quality systems to ensure the highest isotopic purity and chemical integrity. Each batch undergoes rigorous analysis by NMR and Mass Spectrometry to confirm isotopic enrichment and chemical purity. We provide comprehensive Certificates of Analysis (COA) detailing assay, isotopic purity, and solvent content, supporting compliance with GMP/GLP guidelines for use in regulated laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as specified on the label or Certificate of Analysis. For long-term storage, keep under inert atmosphere in a freezer (-20°C). Handle in a well-ventilated area using appropriate personal protective equipment.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98% (chemical purity)
Isotopic Purity	≥98 atom % D
Isotopic Enrichment	≥99% (by MS)
Solvent Content (Residual Solvent)	≤0.5% (by NMR or GC)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.